Publications

Parker CC, Carbonetto P, Sokoloff G, Park YJ, Abney M, Palmer AA (2014) High-resolution genetic mapping of complex traits from a combined analysis of F2 and advanced intercross mice. Genetics 198: 103–116 [pdf]


Campbell CD, Mohajeri K, Malig M, Hormozdiari F, Nelson B, Du G, Patterson KM, Eng C, Torgerson DG, Hu D, Herman C, Chong JX, Ko A, O’Roak BJ, Krumm N, Vives L, Lee C, Roth LA, Rodriguez-Cintron W, Rodriguez-Santana J, Brigino-Buenaventura E, Davis A, Meade K, LeNoir MA, Thyne S, Jackson DJ, Gern JE, Lemanske RF Jr, Shendure J, Abney M, Burchard EG, Ober C, Eichler EE (2014) Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma. PLoS One 9(8):e104396 [pdf]


Yao TC, Hu D, Yang J, Mathias R, Du G, Han L, Roth LA, Nicholas Rafaels, Emma E. Thompson, Dagan A. Loisel, Ying Sun, Caroline A. Motika, Rebecca Anderson, Celeste Eng, Maitane Arruabarrena Orbegozo, Melody Young, James M. Klocksieben, Elizabeth Anderson, Kathleen Shanovich, Lucille A. Lester, L. Keoki Williams, Kathleen C. Barnes, Esteban G. Burchard, Dan L. Nicolae, Mark Abney*, Carole Ober* (* Equal contribution). (2014) Genome-wide association study of lung function phenotypes in a founder population. Journal of Allergy and Clinical Immunology 133(1):248–255 [pdf]

Cheng R, Parker CC, Abney M, Palmer AA. (2013) Practical considerations regarding the use of genotype and pedigree data to model relatedness in the context of genome-wide association studies. G3 3(10):1861–1867 [pdf]

Han L, Abney M (2013) Using identity by descent estimation with dense genotype data to detect positive selection. European Journal of Human Genetics 21:205–211 [pdf]

Campbell CD, Chong JX, Malig M, Ko A, Dumont BL, Han L, Vives L, O’Roak BJ, Sudmant PH, Shendure J, Abney M, Ober C, Eichler EE. (2012) Estimating human mutation rate using autozygosity in a founder population. Nature Genetics 44:1277–1281 [pdf]

Stanhope SA, Abney M (2012) GLOGS: a fast and powerful method for GWAS of binary traits with risk covariates in related populations. Bioinformatics 28:1553–1554. [pdf]

Motika CA, Papachristou C, Abney M, Lester LA, Ober C (2011) Rising prevalence of asthma is sex-specific in a US farming population. Journal of Allergy and Clinical Immunology 128:774-779. [pdf]


Cheng R, Abney M, Palmer AA, Skol AD (2011) QTLRel: an R package for genome-wide association studies in which relatedness is a concern. BMC Genetics 12:66. [pdf]


Parker CC, Cheng R, Sokoloff G, Lim JE, Skol AD, Abney M, Palmer AA (2011) Fine-mapping alleles for body weight in LG/J × SM/J F₂ and F(34) advanced intercross lines. Mammalian Genome 22:563-571. [pdf]


Han L, Abney M (2011) Identity by Descent Estimation with Dense Genomewide Genotype Data. Genetic Epidemiology 35:557-567. [pdf] [supp]


Papachristou C, Ober C, Abney M (2011) Genetic Variance Component Estimation for Binary Traits. Genetic Epidemiology 35:291-302. [pdf]


Cheng R, Lim JE, Samocha KE, Sokoloff G, Abney M, Skol AD, Palmer AA. (2010) Genome-wide Association Studies and the Problem of Relatedness Among Advanced Intercross Lines and Other Highly Recombinant Populations. Genetics 185:1033–1044. [pdf]


Kosova G, Pickrell JK, Kelley JL, McArdle PF, Shuldiner AR, Abney M, Ober C. (2010) The CFTR Met 470 allele is associated with lower birth rates in fertile men from a population isolate. PLoS Genetics 6:e1000974. [pdf]


Kosova G, Abney M, Ober C. (2010) Heritability of reproductive fitness traits in a human population. Proceedings of the National Academy of Sciences 107 (Suppl 1):1772-1778.[pdf]


Abney M (2009) A graphical algorithm for fast computation of identity coefficients and generalized kinship coefficients. Bioinformatics. 25:1561-1563.[pdf] [supplementary material]


Ober C, Nord AS, Thompson EE, Pan L, Tan Z, Cusanovich D, Sun Y, Nicolae R, Edelstein C, Schneider DH, Billstrand C, Pfaffinger D, Phillips N, Anderson RL, Philips B, Rajagopalan R, Hatsukami TS, Rieder MJ, Heagerty PJ, Nickerson DA, Abney M, Marcovina S, Jarvik GP, Scanu AM, Nicolae DL. (2009) Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q. Journal of Lipid Research 50:798-806. [pdf]


Abney M (2008) Identity-by-descent estimation and mapping of qualitative traits in large, complex pedigrees. Genetics 179:1577-1590. [pdf]


McArdle PF, Dytch H, O'Connell JR, Shuldiner AR, Mitchell BD, Abney M. (2007) Homozygosity by descent mapping of blood pressure in the Old Order Amish: evidence for sex specific genetic architecture. BMC Genetics 8:66. [pdf]


Pan L, Ober C, Abney M (2007) Heritability estimation of sex-specific effects on human quantitative traits. Genetic Epidemiology 31: 338–347. [pdf]


Weiss LA, Pan L, Abney M, Ober C (2006) The sex-specific genetic architecture of quantitative traits in humans. Nature Genetics 38: 218–222. [pdf]


Kurina LM, Weiss LA, Graves SW, Parry R, Williams GH, Abney M, Ober C (2005) Sex differences in the genetic basis of morning serum cortisol levels: Genome-wide screen identifies two novel loci specific to women. Journal of Clinical Endocrinology and Metabolism 90: 4747-4752. [pdf]


Weiss LA, Abney M, Parry R, Scanu AM, Cook EH, Ober C (2005) Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample. Human Genetics 117: 81–87. [pdf]


Weiss LA, Abney M, Cook EH, Ober C (2005) Sex-specific genetic architecture of whole blood serotonin levels. American Journal of Human Genetics 76: 33–41. [pdf]


Bourgain C, Abney M, Schneider D, Ober C, McPeek MS (2004) Testing for Hardy-Weinberg in samples with related individuals. Genetics 168: 2349–2361. [pdf]


Weiss LA, Veenstra-VanderWeele J, Newman DL, Kim S-J, Dytch H, McPeek MS, Cheng S, Ober C, Cook EH, Abney M (2004) Genomewide association study identifies ITGB3 as a QTL for whole blood serotonin. European Journal of Human Genetics 12: 949–954. [pdf]


Newman DL, Hoffjan S, Bourgain C, Abney M, Nicolae RI, Profits ET, Grow MA, Walker K, Steiner L, Parry R, Reynolds R, McPeek MS, Cheng S, Ober C (2004) Are common disease susceptibility alleles the same in outbred and founder populations? European Journal of Human Genetics 12: 584–590. [pdf]


Newman DL, Abney M, Dytch H, Parry R, McPeek MS, Ober C (2003) Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree. Human Molecular Genetics 12: 137–144. [pdf]


Abney M, Ober C, McPeek MS (2002) Quantitative trait homozygosity and association mapping and empirical genome-wide significance in large complex pedigrees: Fasting serum insulin levels in the Hutterites. American Journal of Human Genetics 70: 920–934. [pdf]


Newman DL, Abney M, McPeek MS, Ober C, Cox NJ (2001) The importance of genealogy in determining genetic associations with complex traits. American Journal of Human Genetics 69: 1146–1148. [pdf]


Ober C, Abney M, McPeek MS (2001) The genetic dissection of complex traits in a founder population. American Journal of Human Genetics 69: 1068–1079. [pdf]


Sun L, Abney M, McPeek MS (2001) Detection of misspecified relationships in inbred and outbred pedigrees, Genetic Epidemiology 21: S36–S41.


Abney M, McPeek MS, Ober C (2001) Narrow and broad heritabilities of quantitative traits in a founder population, American Journal of Human Genetics 68: 1302–1307. [pdf]


Abney M, McPeek MS, Ober C (2000) Estimation of variance components of quantitative traits in inbred populations, American Journal of Human Genetics 66: 629–650. [pdf]


Ober C, Cox NJ, Abney M, Di Rienzo A, Lander ES, Changylaket B,Gidley H, Kurtz B, Lee J, Nance M, Pettersson A, Prescott J, Richardson A, Schlenker E, Summerhill E, Willadsen S, Parry R and the Collaborative Study on the Genetics of Asthma (1998) Genome-wide search for asthma susceptibility loci in a founder population, Human Molecular Genetics 7: 1393–1398. [pdf]


Lidsey JE, Liddle AR, Kolb E, Copeland EJ, Barriero t, Abney M (1997) Reconstructing the Inflaton Potential—an Overview. Reviews of Modern Physics 69: 373–410. [pdf]


Abney M (1997) Fluctuations and Bubble Dynamics in First Order Phase Transitions, Physical Review D 55: 582–594. [pdf]


Abney M, Epstein R, Olinto A (1996) Observational Constraints on the Internal Structure and Dynamics of the Vela Pulsar, Astrophysical Journal Letters 466: L91. [pdf]


Abney M, Epstein R (1996) Ekman pumping in compact astrophysical bodies, Journal of Fluid Mechanics 312: 327–340. [pdf]


Kolb E, Abney M, Copeland E, Liddle AL, Lidsey JE (1995) The Inflaton Potential from Present Day Observations, Nuclear Physics B Suppl. 43: 118–125. [pdf]


Abney M (1994) Hydrodynamic Detonation Instability in Electroweak and QCD Phase Transitions, Physical Review D 49: 1777–1782. [pdf]