We develop and use tools of equilibrium and non-equilibrium statistical mechanics to understand the behavior of complex systems in physical chemistry, soft condensed matter physics, and biophysics. Specific research directions include: Statistical mechanics of driven systems and self assembly out of equilibrium, information processing and control in biology, and studies of aqueous fluctuations in heterogeneous environments with the goal of developing coarse grained models for efficient multiscale chemical and biophysical simulations.