Mark F. Ciaccio

Doctoral Candidate
Laboratory of Dr. Richard B. Jones, The University of Chicago

Affiliations:

The Ben May Institute for Cancer Research
The Institute for Genomics & Systems Biology
Committee on Cellular and Molecular Physiology
The Center for Systems Biology of Oxygen Sensing



Contact Information:

Mark Ciaccio, Jones Group
Knapp Center for Biomedical Discovery, Room 10240D
900 East 57th St.
Chicago, IL 60637
Home Phone: (773) 454-2600
Email: ciaccio@uchicago.edu

Objective:

To obtain a full-time position with a focus in Systems Biology/Technology Development, specifically with
the intention of expanding the use of the Microwestern Array to diverse fields of biology.


Research:

My current project has been developing the Microwestern Array (MWA) and expanding its capabilities.
Specifically I have been using the MWA to characterize phosphorylation cascades and model cell
phenotype as a function of short-term phosphorylation kinetics of signaling molecules.


Publications:

Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits.
Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, Degrace MM,
Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U,
Jones RB, Park H, Carr SA, Regev A, Amit I, Hacohen N.
Cell. 2011 Nov 11;147(4):853-67.
PMID: 22078882

Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin.
Liu J, Kuo WL, Seiwert TY, Lingen M, Ciaccio MF, Jones RB, Rosner MR, Cohen EE.
Head Neck. 2011 Mar 24. Epub.
PMID: 21438065

Systems analysis of EGF receptor signaling dynamics with microwestern arrays.
Ciaccio MF, Wagner JP, Chuu CP, Lauffenburger DA, Jones RB.
Nat Methods. 2010 Feb;7(2):148-55. Epub 2010 Jan 24.
PMID: 20101245

Systems-level analysis of ErbB4 signaling in breast cancer: a laboratory to clinical perspective.
Chuu CP, Chen RY, Barkinge JL, Ciaccio MF, Jones RB.
Mol Cancer Res. 2008 Jun;6(6):885-91. Review.
PMID: 18567793

Cytosolic prion protein toxicity is independent of cellular prion protein expression and prion propagation.
Norstrom EM, Ciaccio MF, Rassbach B, Wollmann R, Mastrianni JA.
J Virol. 2007 Mar;81(6):2831-7. Epub 2006 Dec 20.
PMID: 17182694

Patents:

Title: Methods and Compositions related to Microscale Sample Processing and Evaluation
Inventors: Richard Jones and Mark Ciaccio
Publication Date: 11.06.2009
Publication Number: WO/2009/073632

Teaching Experience:

Protein Post-Translational Modifications, Lecturer
University of Chicago
Spring Q 2010, 2011
Mentors: Richard Jones, Piers Nash, Yingming Zhao

Cancer Biology IV: Frontiers in Cancer biology, Lecturer
University of Chicago
Spring Q 2011
Mentors: Mark Lingen, Carrie Rinker-Schaeffer, Richard Jones

Relay for Life
Guest Research Speaker
Kankakee, IL June 2010, 2011

Fundamentals of Molecular Biology, Teaching Assistant
University of Chicago, Spring 2008
Mentors: Dr. Ursula Storb, Dr. Jon Staley

Teaching Assistantship Training, Student
University of Chicago Graduate Class, Winter 2008
Mentor: Dr. Nancy Schwartz

English as a Second Language, Teacher
St. Teresa Parish, Kankakee, IL 2001-2003
Mentor: Sr. Josephine Ciaccio

*Examples of personal training lectures available at: http://www.youtube.com/user/RichardBJonesLab

Education:

University of Chicago (Sept. 2006 - Current)
Biological Sciences Division
Committee on Cellular and Molecular Physiology
Doctoral Program

University of Notre Dame (1998-2002)
Notre Dame, IN
College of Engineering
B.S. Biochemical Engineering

Illinois Mathematics and Science Academy (1995-1998)
Aurora, IL
College Preparatory Secondary Education


Additional Information:

Department: University of Chicago: Biological Sciences Division

Mentor: Dr. Richard Jones

Program of Study: Committee on Cellular and Molecular Physiology

Laboratory: Richard B Jones Group

Lab Affiliation: Institute for Genomics and Systems Biology

Lab Affiliation: Ben May Department of Cancer Research

Current work: All about Microwestern Arrays

Press Release: Illuminating Proteins in One Step

Methods Manuscript: Systems analysis of EGF receptor signaling dynamics with microwestern arrays.

Methods Video Tutorials: The Microwestern array.

Funding and Affiliation: The Center for Systems Biology of Oxygen Sensing


Interests:

Microwestern Arrays
Systems Biology
Reactive Oxygen Species
Receptor Tyrosine Kinases
Cell Signaling
Proteins
Technology Development
Cancer Biology
Computational Modeling
Drug Development



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