Research Assistant and PhD Student
Department of Ecology and Evolution
University of Chicago
1101 E 57th St, Z301
Chicago, IL 60637, USA
E-mail: sidichen[at]uchicago.edu
I am working with professor Manyuan Long on new gene evolution. I am
interested in how new genes arise, how they interact with the existing genome
and integrate into the complex network. I use a combination of genetics,
functional genomics and evolutionary analyses to understand the contribution of
recently evolved genes to organismal fitness, which includes survival and
reproduction.
RESEARCH SUMMARY
I am interested in the evolution of
the complex biological systems. In my thesis research, I investigated the
evolution of phenotype and the underlying the gene-gene interaction network
using genetic, biochemical and functional genomics approaches. I studied new
gene origination, which provides ultimate genetic sources to trigger evolution
of these complex processes. I found that functional new genes frequently arise
during evolution, playing essential roles in developmental programs,
reproduction and neural circuits. An on-going project is to characterize the
role of new genes in phenotypic evolution in multiple closely related species.
Brief
CV
SIDI
CHEN
EDUCATION
2006- Ph.D. candidate, Department of Ecology and Evolution,
University
of Chicago (Degree expected 2011)
2009 Visiting student, Department of
Biology, Stanford University,
2006 M.S., Department of Ecology and
Evolution, University of Chicago,
2004 B.S. with honor, College of Life
Sciences, Peking University,
HONORS AND AWARDS
2010 The Best Research Poster Award for
Graduate Students, The 18th Annual Meeting of the international Society of
Molecular Biology and Evolution (the only recipient in the year awarded)
Student Travel Award, Okinawa Institute Winter Course for Evolution of Complex
Systems
Student Travel Award, Gordon Conference on Quantitative Genetics and Genomics
2004-08 Biological Sciences Fellowships, the University of Chicago
2006 Workshop Fellowship, High-throughput Data Analysis, Cold Spring Harbor
Laboratory
2004 Tsun-Chung Scholar for excellence in
research, The Nobel Laureate Lee Chung-Tao Foundation
2002 The Novozyme Fellowship, Peking University,
Sponsored by of the Novozyme Inc, CA
PROFESSIONAL AFFILICATIONS:
The Society of Molecular Biology and
Evolution, 2009-
Genetic Society of America, 2009-
Society for Neuroscience, 2010-
PUBLICATIONS
1. Sidi Chen, Yong Zhang, and Manyuan
Long. New genes in Drosophila quickly become essential. Science
17 December 2010: Vol. 330 no. 6011 pp. 1682-1685 DOI:
10.1126/ science.1196380
2. Sidi Chen, Xiaochun Ni, Benjamin
Krinsky, Yong Zhang, Maria Vibranovski, Kevin White and Manyuan Long.
Evolutionary targets of a male fecundity gene that impacts global sex-biased
gene expression. (In revision).
3. Hongzheng Dai, Ying Chen, Sidi Chen, Qiyan
Mao, David Kennedy, Adam Eyre-Walker, Wei Du and Manyuan Long. The evolution of
courtship behaviors through the origination of a new gene in Drosophila. Proc Natl Acad
Sci USA. 2008 May 27;105:7478-83. Epub 2008 May 27.
4. Keqiang Fan, Ping Wei, Qian Feng,
Sidi Chen,
Changkang Huang, Liang Ma, Bing Lai, JIanfeng Pei, Ying Liu, Jianguo Chen and
Luhua Lai. Biosynthesis, purification, and substrate specificity of severe
acute respiratory syndrome coronavirus 3C-like proteinase. J Biol Chem. 2004 Jan 16;279(3):1637-42.
Epub 2003 Oct 15.
5. Xi Chen, Qian Feng, Zhiying Wu,
Yingying Liu, Kun Huang, Rui Shi, Sidi Chen, Wen Lu, Mingxiao Ding, Richard
Collins, Yin-Wan Wendy Fung, Lok-Ting Lau, Albert Cheung-Hoi Yu and Jianguo
Chen. RNA-dependent RNA polymerase gene sequence from foot-and-mouth disease
virus in Hong Kong. Biochem
Biophys Res Commun. 2003 Sep 5;308(4):899-905.
Last updated Jan 3rd 2011
The main page for personal home
pages at the University of Chicago
The University of Chicago main home page